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Scientists one step closer to delaying the ageing process..Until then, BOTOX!

Scientists one step closer to delaying the ageing process...Until then, Botox!



Getting old is inevitable, but scientists at the University of California San Diego (UCSD) may be one step closer to being able to delay the ageing process.
A team of scientists studied ageing in yeast -- chosen because its cells are easily manipulated -- to try and understand if different cells age at the same rate, and for the same reason.
What they found was intriguing. Even cells made of the same genetic materials and within the same environment aged in "strikingly distinct ways," according to the scientists, who published their findings in the journal Science.
ABOVE: Yeast cells with the same DNA under the same environment show different structures of mitochondria (green) and the nucleolus (red), which may underlie the causes of different aging paths. Single and double arrowheads point to two cells with distinct mitochondrial and nucleolar morphologies. (University of California)
About half of the yeast cells aged because of a gradual decline in the nucleolus, a round body located in the nucleus of a cell, the scientists learned, by using techniques including microfluidics and computer modelling.
However, the other half aged because of a dysfunction of mitochondria, which produce a cell's energy.
Scientists said that the cells go down one of two paths -- nuclear or mitochondrial -- early in life, and they continue with the ageing route until they ultimately decline and die.
Researchers performed further tests to understand how the cells behaved.
"To understand how cells make these decisions, we identified the molecular processes underlying each ageing route and the connections among them, revealing a molecular circuit that controls cell ageing, analogous to electric circuits that control home appliances," Nan Hao, senior author of the study and an associate professor in UCSD's division of biological sciences' molecular biology section, said.
After modelling the "ageing landscape," the team of researchers found they could manipulate -- and optimise -- the process of ageing, using computer simulations to reprogram the master circuit and modify its DNA.
They were then able to create a "novel ageing route," with a dramatically extended lifespan. This, researchers believe, could ultimately lead to the possibility of delaying human ageing.
"This is an ageing path that never existed, but because we understand how it is regulated, we can basically design or regulate a new ageing path," Professor Hao told CNN.
"Our study raises the possibility of rationally designing gene or chemical-based therapies to reprogram how human cells age, with a goal of effectively delaying human ageing and extending human health span," he said in a statement.
Scientists said that they plan to test their model in complex cells, organisms, and eventually, humans, as well as testing how combinations of therapeutics and drugs could lead to further longevity.
"Ageing is a fundamental biological question. We know very little about the ageing process," Professor Hao told CNN.
When it comes to medical relevance, he said, "ageing is related to many diseases so if we can help slow ageing or promote longevity, it will be beneficial for society."